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Lack of association between CD45 C77G polymorphism and multiple sclerosis in Kashmir

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Lack of association between CD45 C77G polymorphism and multiple sclerosis in Kashmir


Insha Zahoor | Amrina Shafi | Mudasir A Mir

https://doi.org/10.31142/ijtsrd5813



Insha Zahoor | Amrina Shafi | Mudasir A Mir "Lack of association between CD45 C77G polymorphism and multiple sclerosis in Kashmir" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6, October 2017, pp.1333-1337, URL: https://www.ijtsrd.com/papers/ijtsrd5813.pdf

Multiple sclerosis (MS) is a severe disabling and demyelinating disease of the nervous system. Its etiology involves profound genetic component. The latest contender known to have been correlated with MS is protein tyrosine phosphatase receptor-type C (PTPRC or CD45); however, to date its role remains contentious. The aim of the current study was to examine the association of functionally significant exon 4 C77G polymorphism of CD45 with MS in Kashmiri population from Indian subcontinent. The preliminary findings of our study revealed absence of C77G in majority of the cases as well as controls. These findings strongly suggest that the alterations in CD45 are sporadically associated with the genesis of MS. In conclusion, results from our study are in accordance with some of the international studies; however, more studies with large datasets from Kashmir as well as other ethnic populations are warranted to validate the above preliminary findings and demonstrate the role of CD45 C77G polymorphism in MS pathogenesis.

MS; genetics; CD45; C77G; polymorphism; Kashmir


IJTSRD5813
Volume-1 | Issue-6, October 2017
1333-1337
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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