Diabetes mellitus is an autoimmune disorder which causes impairment in the insulin secretion or resistance. The prevalence of Diabetes is increasing day by day worldwide, also this metabolic disorder diseases is associated with high risk of cardiac problem, obesity and many other diseases. Although, there are different medications and treatments are available but still they have proven to be ineffective and associated with severe adverse effects for long term. Therapeutic compounds based on herbal phytochemicals are considered as the most prominent for the treatments. The computational study helps in finding the structural basis analysis of the compounds by rapid screening tools with rational drug designing. This study aims to identify the natural inhibitor of Rad-GTP binding protein to treat Diabetes dysfunctionality.Therefore, by searching the natural compounds against Rad-GTPase binding protein with 2DPX structure, all the important data was retrieved by using online webservers followed by computing docking score in AutoDock Vina. Out of three selected compounds, Gedunin was used to dock with the protein 2DAX protein structure, as it follows the both criteria for proceeding further, one is to follow lowest binding criteria then ADME (Absorption, Distribution, Metabolism and excretion). The docking score of Gedunin compound shows that, this bioactive agent can go against the Diabetes mellitus and inhibits the expression of Rad-GTPase. By result Gedunin has shown its therapeutic role with -7.9 kcal/mol value. It has been concluded that in future Gedunin may act as a novel drug target.
Diabetes, Rad-GTP ase, herbal phytochemical and Drug discovery
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