Diabetes is one of the major causes of death in the world, affecting around 422 million people (or 8.5 percent of the world's population). Diabetes mellitus, or diabetes, is a disease that causes excessive blood sugar levels. Diabetes mellitus is a condition where a person does not produce enough insulin or does not link directly to insulin, and resulting in excessively high blood sugar (glucose) levels. Diabetes is classified into several types: Prediabetes, Type 1 diabetes, Type 2 diabetes and gestational diabetes. In diabetes research, numerous bioinformatics technologies are used. The current research was carried to study the effect of naturally occurring compounds against Aquaporin 2 as the target protein molecule with the help of molecular docking for diabetes diagnosis. AQP2 is found in the apical cell of the main ducts of the kidney and in the vesicles (intracellular) in the cells. Docking experiment were performed out by using aquaporin 2 (4nef). The technique of molecular docking was utilized to investigate the potential of naturally occurring compounds such as aglycone, gedunin, and harman with the target protein Aquaporin 2 (4nef). In diabetes, gedunin may function as a therapeutic drug against the disease-causing protein Aquaporin 2 (4nef). Further research and then certain clinical and pre-clinical studies may be allowed to discover drugs that can be used to treat diabetes.
Diabetes, Molecular Docking, Aquaporin 2 (4nef), Gedunin, Autodock
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