<b>A Review on Therapeutic Indication of Yashtimadhu Glycerrhiza Glabra Linn W.S.R. to Charaka Samhita</b> Herbal medicinal plants play an important role in the traditional systems of medicine such as Ayurveda, Unani, Siddha. Because of minimal side effects and records of safety the demand of herbal medicines is increasing tremendously. Ayurveda, the science of life is as old as Vedas. It is the science that advocates the maintenance of health and relieves human sufferings. Charaka Samhita is an old ancient literature of Ayurveda written by Acharya Charaka and healing is the hallmark of Charak Samhita 2nd century AD marks the period of Charaka Samhita. It is written in 8 Sthanas in total 120 Adhyayas. The ancient Indian physician Acharya Charaka had included Yashtimadhu not only in Medhya Rasayana but also gives place in almost eleven Mahakashaya out of fifty knowing its medicinal importance. Yashtimadhu has got various medicinal therapeutic properties such as Jeevaneeya, Sandhaniya, Varnya, Kandughna, Snehopaga, Vrushya, Kanthya, Twachya and mainly as Medhya etc. Yashtimadhu contains the major compounds as – glycyrrhizin, glucose, sucrose, resin and fat etc. Hence, in the present study, an attempt is made to critically review the Yashtimadhu i.e. Glycerrhiza glabra Linn through ancient Indian classical Ayurvedic text popularly known as Charaka Samhita. Yashtimadhu, Glycerrhiza glabra, Ayurveda, Charaka Samhita 43-49 Issue-4 Volume-7 V. B. Washimkar | Sarang P. Lakhmale | Manoj P. Rathod