<b>Formulation and Evaluation of Mouth Dissolving Tablets of Losartan Potassium</b> Losartan Potassium is an angiotesion II receptor antagonist and used as antihypertensive drug. The molecular weight of Losartan Potassium is 461.0 g mole, half life is 1.5 to 2 hours, and its bioavailability is1 25 35 . It gets metabolized mainly in the liver but have good buccal absorption. Mouth dissolving tablets will be the better option for formulation of Losartan Potassium as far as tablet dosage form is concern. Mouth dissolving tablets are soluble in saliva and absorbed from the mouth. thus enhance the bioavailability by avoiding first pass metabolism. Mouth dissolving tablets also leads to an increased patient compliance, and fast onset of action. Mouth dissolving tablets were prepared by direct compression method using natural super disintegrating agents banana powder and evaluated for pre compression parameters and post compression parameters such as appearance, dimensions, hardness, weight variation, friability, wetting time, dispersion time, water absorption ratio, disintegration and dissolution study. According to results of optimized batches it has been concluded that formulation batch F10 was an ideal batch which contain banana powder and crosscarmellose sodium showed least disintegration time that is 61 seconds and maximum drug release of 98.42 within 10 minutes and was best among all the formulations. Losartan Potassium, mouth dissolving tablets, natural super disintegrating agent banana powder and synthetic super disintegrating agent crossprovidone and croscarmellose sodium 32-41 Issue-5 Volume-6 Swapnil Khade | Prof. Mrs. Trusha P. Shangrapawar | Dr. Ashok Bhosale