<b>A Study to Assess the Knowledge and Practice Regarding Occupational Blood and Body Fluid Exposure among Staff Nurses in Selected Hospitals at Lucknow</b> Background Occupational exposure is the exposure to the blood and body fluids .The mode of exposure includes percutaneous, mucocutaneous and non intact skin exposure. Occupational blood and body fluid BBF exposures place healthcare workers HCW at risk for numerous blood borne infections, most importantly human immunodeficiency virus HIV , hepatitis B virus HBV , and hepatitis C virus HCV .1A Descriptive Correlational Study was conducted to assess the knowledge and practice regarding occupational blood and body fluid exposure among staff nurses in selected hospitals at Lucknow. The Objectives of the study were to assess the knowledge and practice of staff nurses regarding occupational blood and body fluid exposure. Find determine the correlation between the level of knowledge and practice and find out association of knowledge and practice with selected socio demographic variables regarding occupational blood and body fluid exposure. Methodology The research approach adopted for the study is non experimental approach. The researcher selected 100 staff nurses worked in two selected Hospital, Lucknow using convenience sampling technique. Result The results revealed that majority of subjects 60 were having moderately adequate knowledge, 23 had adequate knowledge and 17 had inadequate knowledge. Among 100 staff nurses 39 had inadequate practice, 46 had moderately adequate practice and 15 had adequate practice. The Karl Pearson’s coefficient correlation formula was used and it showed that r = 0.898 with statistically evidenced positive correlation which is significant at 0.01 level. The association between level of knowledge and practice with socio demographic variables were identified by using Chi square test The demographic variables such as age, professional qualification, years of experience in nursing were found to be significant with level of knowledge. The demographic variables such as age, professional qualification, years of experience in nursing were found to be significant with level of practice. Conclusion This study finding motivates the staff nurses to upgrade knowledge and improve practice regarding occupational blood and body fluid exposure. Knowledge, Practice, Occupational blood and body fluid exposure, Staff nurse 1-9 Issue-4 Volume-6 Shradha Mishra | Rajni