<b>Effectiveness of Nurse Led Heart Failure Management Program on Quality of Life of Heart Failure Patients in Cardiology OPD, at KGMU, U.P</b> Background Heart failure HF is characterized by poor quality of life QOL with high hospitalization rates, and poor prognosis. Younger age groups are more affected in developing countries like India. HF can be very disabling, and QOL of patient s can be severely affected Objectives 1. To assess the Quality of Life of Heart Failure patients in Experimental and Control Group. 2. To Compare the effectiveness of Nurse Led Heart Failure Management Program on Quality of life of heart failure patients in Experimental and Control Group. Method The study was conducted for 3 months from 1 Dec to 1 March 2019, in cardiology OPD, at KGMU, U.P, based on simple random sampling the groups were divided into control group and experimental group in which the control group received no intervention and Interventions of Nurse led Heart failure management program was given in experimental group with a Log book which they have to fill once a week for 3 months. Post test questionnaire for Quality of life and log book data will be collected from both the groups after 3 months. Results The result showed significant difference between Quality of life P 0.002 as measured by KCCQ, mean Quality of life was found to be significantly higher among the subjects of Experimental group 60.50±12.10 than control group 46.73±16.23 at post intervention. Conclusion Simple systemic educational intervention that was targeted towards patient to provide a tailored educational intervention through an holistic Perspective, focused on preserving or enhancing health and Self management goal achievement has improve quality of life of heart failure patients those who received NLP i.e, Experimental group, Their Quality Scores were High as Compared to Control group. Conclusion The study concluded that, structured information brochure is an effective way to improve the knowledge and reduce the anxiety among the patient planned for angioplasty. The study recommended that structured information brochure about the post procedural care about the angioplasty should be implemented to improve the knowledge and reduce the anxiety among the patient for providing a better care. Quality of life, KCCQ, Nurse Led Heart Failure Management Program 1502-1508 Issue-1 Volume-6 Richi Lal | Rashmi P. John | Sharad Chandra