<b>Histopathological Effects of Gamma Radiation on Adhatoda Vasica Treated Biceps Muscle</b> The objective of the present study was to evaluate Adhatoda vasica extract administered and radiation induced changes in the biceps muscle of Swiss Albino male mice. Animals were divided into four groups Group I containing normal mice served as control for each experimental stage, mice of Group II received oral administration of Adhatoda vasica extract 900mg kg body weight , mice of group III received oral administration of Adhatoda extract and were irradiated with 4Gy –rays, mice of group IV were irradiated with 4Gy radiation. Adhatoda extract was administered orally to the animals 900mg kg body weight for a period of 28 days. After 7 days of extract administration mice were irradiated with 4 Gy rays. 24 hours after irradiation mice were sacrificed by cervical dislocation on days 7, 14, 21 and 28. Excised tissue was fixed in 10 neutral formalin. Sections of 5µm thickness were stained with hematoxylin and eosin for histopathological examination. Histological changes in the mice biceps were observed between 7 28 days of investigation. Extract treated group of mice showed no alterations in the biceps muscle structure. Mice which were pretreated with extract and then irradiated showed compact arrangement of cells but with changes in shape of fibers. In the irradiated group, myonecrosis and splitting of fibers were observed. Interfibrillar spaces were enlarged. Heterogeneous population of muscle cells were seen. Irradiation causes damage to muscle tissue while Adhatoda extract minimized the damage. Radiation, Adhatoda vasica, Biceps, Swiss Albino Mice, Myonecrosis 177-182 Issue-6 Volume-5 Anupam | Sushma Sharma