A Review on Epileptic Treatment by Levetiracetam
Background Levetiracetam is a novel antiepileptic drug. It is marketed worldwide since 2000. Aim The paper reviewed the mechanism of action, pharmacokinetics, adverse drug reactions, contraindications and uses of levetiracetam in the treatment of various types of epileptic seizures. Methods Literature searches were done to identify relevant studies. Results Levetiracetam acts by binding to the synaptic vesicle protein SV2A, thereby modulation of one or more of its actions and ultimately affecting neural excitability. It has less protein binding and lacks hepatic metabolism. In contrast to traditional therapy, it has a wide safety margin and does not require serum drug monitoring. It does not interact with other anti epileptics. Conclusion The above mentioned favourable pharmacological benefits of LEV make it an important first line or adjunctive therapy for epileptic seizures.
Levetiracetam, epilepsy, synaptic vesicle protein, seizures, efficacy, safety
Parth Nikam | Rishikesh Bachhav