<b>Natural Compounds as Adjuncts for Treating Colon Cancer through Apoptotic Pathway</b> Cancer is one of the deadliest diseases which is caused when abnormal cells divide uncontrollably and destroy body tissue. Colorectal cancer CRC , also known as colon cancer, is one of the most common type of cancers in humans is closely linked to the global cancer – related mortalities worldwide. The ongoing clinical treatment for colorectal cancer or colon cancer largely engages surgery and chemotherapy. But as there are many side effects and due to emergence of drug resistance, it has become very necessary to find novel and more effectual drugs for colon cancer treatment. Chemo prevention, a novel method for controlling cancer encompasses the use of specific natural products or synthetic chemical agents to reverse, suppress or prevent premalignancy before the development of invasive cancer. Many studies have signified that various natural products have efficacious anti CRC effects and may be used as substitutional chemotherapy agents for CRC therapy. Various natural compounds have been shown to be promising on the basis of their anti cancerous effects and low toxicity. In this review we summarise the natural compounds having anti CRC effects from distinct sources. This review suggest that they provide a novel opportunity for treatment of colon cancer. Colon cancer, Apoptosis, Natural compounds, Caspases, Anti cancer 644-652 Issue-4 Volume-5 Sarita Negi | Nikita Kaushik | Runjhun Mathur | Abhimanyu Kumar Jha