<b>GC–MS Analysis of Bioactive Compounds Present in Ethanol Extract of Panicum Maximum Jacq Leaves</b> Phytoconstituents present in the ethanolic extract of Panicum maximum leaves were explored by Gas Chromatography Mass Spectrometry analysis. The compounds were identified by the gas chromatography coupled with the mass spectrometry. The molecular weight and structure of the compounds of Panicum maximum leaves were ascertained by interpretation of the spectrum of GC MS using the database of National Institute of Standard and Technology NIST . GC MS analysis of Panicum maximum leaves revealed the presence of nineteen biological active compounds. The compounds are benzenamine, 4,4 2 4 nitrophenyl ethenylidene bis N,N dimethyl , cyclopropanecarboxylic acid, 1 phenylmethyl , 2,6 bis 1,1 dimethylethyl 4 methylphenyl ester, 4,5 bipyrimidine 2,2 diamine, 4 ,6 dimethoxy N,N,N ,N tetramethyl , 12 Hydroxystearic acid, phenacyl ester, azadirachtin, de E 2 methyl 1 oxo 2 butenyl 1,2 dioxopropyl dihydro , tricyclo 3.3.1.1 3,7 decane, 1,2,2,3,4,4,6,6,8,8,9,9,10,10 tetradecafluoro 5,7 bis trifluoromethyl , spiro cyclohexane 1,3 3H indole 2 carboxy o toluidide, 7 methyl , 1,3,5 triazine 2,4,6 triamine, N ,N bis 3 aminophenyl N,N diphenyl ,4 dehydroxy 2 ,3 ,3 ,4 ,5,6 ,7 hepta O methylisoorientin, 9,10 anthracenedione, 1,4 bis 2 ethyl 6 methylphenyl amino , l valine, n heptafluorobutyryl , heptadecyl ester, pyrimido 5,4 d pyrimidine, 4,8 di m anisidino 2,6 diethoxy , 2,3,7,7,12,13,17,18 Octaethyl 21H,23H porphine 8 one, 6 fluoro 2 trifluoromethylbenzoic acid, 2 formyl 4,6 dichlorophenyl ester, 2 hydroxyskatole, benzo f cyclopenta a quinolizine 6,7,7a,8,9,10 8H hexacarboxylic acid, 6,7 dihydro , hexamethyl ester, ethyl 2 butyl 3 ethoxycarbonyl methyl amino crotonate , quinoxaline, 2,3 dimethyl , 4H 1 benzopyran 4 one, 5,6 bis acetyloxy 2 3 acetyloxy 4 methoxyphenyl 3,7 dimethoxy It was concluded that the bioactive compounds support the use of Panicum maximum leaves in the treatment of diseases like cancer, diabetes and hypertension. Ethanol, gas chromatography, mass spectra, Panicum maximum, plant 449-456 Issue-5 Volume-4 O. V. Ikpeazu | I. E. Otuokere | K. K. Igwe