<b>Service Encounter Quality and Patients’ Loyalty The Moderated Mediation Role of Gender Difference and Patient Satisfaction</b> Will a smiling worker make a distinction in a service conveyance, and do men and ladies assess emotional signals differently in a practical service experience setting The literature suggests a supportive emotional presentation of consumer reactions to service experiences, but the effect on these evaluations of sexual orientation gender remains hazy. The main aim of this analysis was to evaluate the interceding effect of customer satisfaction on the relationship between quality of service experience and patient experience loyalty, as well as the directing role of sexual orientation gender in driving such impact. The study was anchored on the service encounter needs theory with literature from preceding studies used to develop a conceptual model and hypotheses which were tested using statistical techniques. The study employed a path modelling analysis approach with a cross sectional research design. Sampling was done via census sampling technique and a sample of 562 hospital out patients from four leading private hospitals in Ghana drawn and used in the study. The results showed that the influence of service encounter quality on patient loyalty was partially mediated by patient satisfaction ß = 0.116 t value = 1.956 p= 0.051 and that there was a direct relationship between service encounter quality and customer satisfaction ß = 0.825 t value = 20.092 p= 0.000 moderated by the gender of the patients ß = 0.300 t value = 4.954 p= 0.000 . Patients expect that a service is performed right without errors the very first time its encountered, therefore, the hospital management must ensure their staff are competent and that other facilities that enhance patients experience during it service delivery do meet the patient’s expectations. It’s recommended that policy makers and management of private hospitals in Ghana should improve on service encounter quality and actively pay attention to patients’ expectations especially with their gender as a factor. Future research can moreover be coordinated at the consideration of other varied components age, education, salary, conjugal status, occupation etc. in one integrated study in an attempt to offer additional enlightenment and explanations in regards to the quality of service encounters, patients’ expectations, perceptions and satisfaction in the hospital sub sector. Service Encounter Quality SEQ , Gender, Patient Satisfaction, Patient Loyalty, Healthcare Delivery 406-416 Issue-5 Volume-4 Bentum-Micah Geoffrey | Ma Zhiqiang | Wang Wenxin | Atuahene A. Sampson | Bondzie-Micah Victor | Moses A. Ameyaw