<b>Prevalence of Gene Polymorphisms in Intervertebral Disc Degenerative Diseases</b> Intervertebral disc diseases is otherwise known as breakdown of one or more discs that separate the bone of the spine, Which cause pain in the back, neck as well as frequent pain in legs and arms. The general role of intervertebral discs is to provide the cushioning between vertebrae and absorb the pressure that is exerted on the spine. Generally low back pain LBP is considered as common disorder from disc degenerative diseases. The main reason of the LBP is due to contribution of intervertebral disc diseases and combination of genetic and environmental factors. Most of these factor identified , But some of these remain unidentified. However recent researches identified that variations in several genes may influence the risc of intervertebral disc diseases . Most of the variations associated with genes related with immune function leads to increase risk of intervertebral disc diseases . Most of these genes plays a vital role in immune response like inflammation and water loss dehydration of the discs, Which causes their degeneration. This review focuses on the evidence of genetic disposition, the genes or biological processes that are implicated, and the need to consolidate resources and clarify phenotype definition to take advantage of the new technologies in genetic analysis to enhance our understanding of this condition. Genetic factor, Intervertebral disc degeneration , Degenerative disc disease , intervertebral disc degeneration, low back pain, nucleus pulposus, annulus fibrosus, endplate, extracellular matrix, Polymorphism 292-298 Issue-2 Volume-3 Mr. C. Marimuthu | Dr. V. Pushpa Rani | Dr. V. Judia Harriet Sumathy